TABLE 2

Results of regions of MLS ≥1.18 from the multipoint linkage analysis on chromosome 6

GroupCytogenetic locationDistance from p-terminal (cM)Marker genotyped at the peakMLSNPL scoreEmpirical chromosomal P*
Entire group
 First set6q21–q23128.9D6S10403.513.360.003
 Second set6q22–q23137.7D6S10092.712.970.003
 Combined set6q21–q23128.9D6S10406.234.48<0.001
Age-at-diagnosis <40 years subgroup
 First set6q21–q23128.9D6S10401.292.000.013
 Second set6q15–q21102.8D6S10561.742.260.010
 Combined set6q22–q23137.7D6S10092.472.840.011
Age-at-diagnosis ≥40 years subgroup
 First set6q21–q23128.9D6S10402.292.730.008
 Second set6q22–q23137.7D6S10091.792.430.001
 Combined set6q21–q23128.9D6S10404.333.74<0.001
  • *

    * Results from analysis of 1,000 replicates of the respective sets.