TABLE 3

Results of regions with MLS ≥1.18 from the multipoint linkage analysis on chromosome 1

GroupCytogenetic locationDistance from p-terminal (cM)Marker genotyped at the peakMLSNPL scoreEmpirical chromosomal P*
Entire group
 Second set1p35–p3445.3D1S5521.372.090.078
1q21–q24192.1D1S15891.832.540.057
 Combined set1q21–q24192.1D1S15891.162.000.043
Age-at-diagnosis <40 years subgroup
 First set1q21–q25192.1D1S15893.263.390.001
 Second set1p36–p3437.1GATA29A054.364.10<0.001
1p22–p13109.0D1S17283.393.310.005
1q21–q24192.1D1S15896.064.84<0.001
 Combined set1p36–p3529.9D1S15972.172.550.028
1q21–q24192.1D1S15898.915.70<0.001
  • *

    * Results from analysis of 1,000 replicates of the respective sets.