TABLE 1

Mean body weight, blood glucose, and food consumption at day 0 and 60 in placebo-treated db/+ mice, RAGE antibody–treated db/+ mice, placebo-treated diabetic db/db mice, and RAGE antibody–treated db/db mice

Day 0
Day 60
Body weight (g)Blood glucose (mmol/l)Food consumption (g/24 h)Body weight (g)Blood glucose (mmol/l)Food consumption (g/24 h)
db/+
 Placebo20.2 ± 0.36.0 ± 0.34.5 ± 0.522.0 ± 0.45.9 ± 0.34.6 ± 0.4
 RAGE antibody19.8 ± 0.65.6 ± 0.44.7 ± 0.321.5 ± 0.45.5 ± 0.54.9 ± 0.5
db/db*
 Placebo42.4 ± 0.919.5 ± 1.110.8 ± 0.950.3 ± 0.822.0 ± 0.611.2 ± 0.9
 RAGE antibody41.3 ± 1.320.1 ± 1.010.3 ± 0.849.1 ± 0.921.2 ± 0.910.9 ± 0.8
  • Data are means ± SE; n = 6–10 in each group.

  • *

    * P < 0.01 vs. db/+ mice.