TABLE 2

Mean serum insulin, liver weight, and heart weight at day 60 in placebo-treated db/+ mice, RAGE antibody–treated db/+ mice, placebo-treated db/db mice, and RAGE antibody–treated db/db mice

Serum insulin (μg/l)Liver weight (mg)Heart weight (mg)
db/+
 Placebo3.86 ± 0.391,095 ± 37106 ± 4
 RAGE antibody4.20 ± 0.391,094 ± 48104 ± 6
db/db
 Placebo20.31 ± 2.80*2,177 ± 67*110 ± 3
 RAGE antibody18.11 ± 2.54*2,048 ± 90*106 ± 3
  • Data are means ± SE; n = 6–10 in each group.

  • *

    * P < 0.01 vs. db/+ mice.