TABLE 3

Mean kidney NFκB and eNOS at day 60 in placebo-treated db/+ mice, RAGE antibody–treated db/+ mice, placebo-treated db/db mice, and RAGE antibody–treated db/db mice

NFκB (AU)eNOS (AU)
db/+
 Placebo9.8 ± 1.710.4 ± 0.7
 RAGE antibody6.7 ± 0.1*11.0 ± 0.4
db/db
 Placebo5.7 ± 0.6*13.5 ± 0.5
 RAGE antibody5.2 ± 0.7*12.4 ± 0.4
  • Data are means ± SE; n = 6–10 in each group.

  • *

    * P < 0.05 vs. placebo-treated db/+ mice;

  • P < 0.01 vs. db/+ mice;

  • P < 0.05 vs. db/+ mice. AU, arbitrary units.