TABLE 2

Changes in pancreatic tissue and islet cell mass, islet α-cell percentage, and average islet cell size in PID mice

Control (5)PID (5)P
Female mice
    Body weight (g)22.4 ± 0.821.8 ± 0.8NS
    Pancreas mass (mg)189 ± 11199 ± 7NS
    Islet cell mass (mg)0.865 ± 0.1242.002 ± 0.034<0.0001
    Islet mass/body weight (mg/kg)38.4 ± 5.192.5 ± 4.2<0.0001
    Islet percentage0.469 ± 0.0781.021 ± 0.0690.0008
    Islet density (per cm2)14.9 ± 1.124.5 ± 2.10.0039
    Average islet cell size (μm2)632 ± 14 (35)786 ± 16 (62)<0.0001
    Islet α-cell percentage16.3 ± 1.1 (10)4.3 ± 0.4 (10)0.0001
Male mice
    Body weight (g)29.2 ± 2.129.3 ± 1.7NS
    Pancreas mass (mg)252 ± 24217 ± 21NS
    Islet cell mass (mg)1.161 ± 0.0482.667 ± 0.3610.0033
    Islet mass/body weight (mg/kg)40.8 ± 4.492.6 ± 15.20.0088
    Islet percentage0.476 ± 0.0481.291 ± 0.2400.01
    Islet density (per cm2)12.9 ± 1.123.0 ± 3.80.034
    Average islet cell size (μm2)601 ± 27 (30)1,110 ± 78 (44)<0.0001
    Islet α-cell percentage13.0 ± 1.1 (10)5.3 ± 0.6 (10)0.0001
  • Data are means ± SE (n). Number of islets analyzed for islet α-cell percentage and islet cell size are indicated in parentheses. Female and male PID mice 3 months of age were analyzed. P values are derived from comparison with control littermates using unpaired t test.