TABLE 1

Individual associations of the HLA-DRB1/DQB1 and INS genotypes with type 1 diabetes in the Sardinian population

PatientsControl subjectsP/C ratioARPOR95% CIP
DRB1-DQB1
    High risk574 (60.8)77 (7.5)8.13.7195.365.0–139.73.5 × 10−185
    Intermediate risk324 (34.3)358 (35.0)1.00.4511.68.3–16.23.1 × 10−59
    Low risk46 (4.9)588 (57.5)0.080.041
    Total9441,023
INS
    I/I748 (79.2)662 (64.7)1.20.562.71.6–4.71.7 × 10−4
    I/III177 (18.8)315 (30.8)0.60.281.40.8–2.4>0.05
    III/III19 (2.0)46 (4.5)0.40.211
    Total9441,023
  • Data are n (%) unless otherwise indicated. PORs were calculated using as reference genotypes the baseline categories (the HLA low-risk genotype for HLA-DRB1/DQB1 and the VNTR class III/III genotype for INS, respectively).