TABLE 2

Genotype distribution and allele frequencies of the Asp358Ala polymorphism of the IL6R in 1,349 type 2 diabetic patients and in 4,596 glucose-tolerant subjects

Type 2 diabetesNGTPPrecessivePdominantOR (95% CI)
n (men/women)1,349 (819/530)4,596 (2,136/2,460)
Asp/Asp509 (37.7%)1612 (35.1%)
Asp/Ala647 (48.0%)2180 (47.4%)
Ala/Ala193 (14.3%)804 (17.5%)0.0190.0080.068
Ala allele38.3 (36.5–40.1)41.2 (40.2–42.2)0.007
Asp/Asp vs. Ala/Ala1.38 (1.09–1.71)
Asp/Asp vs. Asp/Ala1.08 (0.93–1.26)
Asp/Ala vs. Ala/Ala1.25 (1.02–1.53)
  • Data are number of subjects with each genotype (% of each group) and % (95% CI) unless otherwise indicated. P comparing case versus control subjects in a codominant model, recessive model (Precessive), and dominant model (Pdominant).