TABLE 3

Main clinical and metabolic characteristics in the UCP2 genotypic subgroups of 147 obese children and in 17 age-matched nonobese children.

UCP2 genotypeObese children
Lean children
−866 G/G−866 G/A−866 A/A
n55751714
Male/female21/3430/4512/57/7
Age (years)11.7 ± 0.311.5 ± 0.310.9 ± 0.611.9 ± 0.7
BMI (kg/m2)28.8 ± 0.729.6 ± 0.627.6 ± 0.718.1 ± 0.8*
Fasting glucose (mmol/l)4.2 ± 0.04.1 ± 0.04.2 ± 0.14.3 ± 0.1
Fasting insulin (pmol/l)88 ± 698 ± 779 ± 654 ± 4*
Free fatty acid (mmol/l)0.61 ± 0.040.58 ± 0.030.53 ± 0.050.51 ± 0.10
Non protein respiratory quotient0.844 ± 0.0100.838 ± 0.0700.865 ± 0.0160.900 ± 0.020
Resting energy expenditure/lean body mass43 ± 149 ± 255 ± 846 ± 4*
Glucose oxidation rate (mg · m−2 · min−1)71 ± 469 ± 394 ± 10136 ± 6*
Lipid oxidation rate (mg · m−2 · min−1)33 ± 234 ± 126 ± 325 ± 5*
Calories from glucose/calories from lipids1.75 ± 0.411.23 ± 0.183.59 ± 1.23§5.45 ± 0.55*
  • Data are means ± SE.

  • *

    * P < 0.01 vs. the whole cohort of 147 obese children;

  • P < 0.05 vs. G/A, P < 0.03 vs. A/A;

  • P < 0.005 vs. G/A, P < 0.02 vs. G/G;

  • §

    § P < 0.001 vs. G/A, P = 0.07 vs. G/G.