TABLE 1.

Hormone concentrations in 42-h-fasted conscious dogs receiving intraportal insulin and glucagon infusions at basal rates, intraportal glucose infusion, and peripheral infusions of NA, NAG, or NAL

Parameter and groupStudy period
BasalPeriod 1Period 2
Arterial plasma insulin (pmol/l)
 NA50 ± 1034 ± 637 ± 6
 NAG46 ± 2836 ± 1443 ± 17
 NAL47 ± 1032 ± 734 ± 8
Hepatic sinusoidal plasma insulin (pmol/l)
 NA141 ± 26137 ± 12149 ± 22
 NAG109 ± 65131 ± 34148 ± 31
 NAL147 ± 43127 ± 20151 ± 28
Arterial plasma glucagon (ng/l)
 NA38 ± 437 ± 434 ± 4
 NAG30 ± 233 ± 330 ± 3
 NAL44 ± 435 ± 533 ± 4
Hepatic sinusoidal plasma glucagon (ng/l)
 NA42 ± 551 ± 447 ± 4
 NAG34 ± 451 ± 445 ± 4
 NAL51 ± 453 ± 547 ± 5
Arterial plasma cortisol (nmol/l)
 NA93 ± 12121 ± 1467 ± 7
 NAG104 ± 26103 ± 3570 ± 4
 NAL139 ± 3199 ± 1660 ± 8
  • Data are means ± SE of two sampling points during the basal period and 5 sampling points during periods 1 and 2. There were no significant differences among groups (n = 7, 3, and 8 for NA, NAG, and NAL, respectively).