TABLE 2

Kidney hemodynamic and filtration function data obtained from FITC inulin and PAH clearance assays

		2 months	3 months	5 months	9 months
n		4	8	6	9
Body weight (g)	FVB	22.0 ± 0.2	24.9 ± 1.2	27.5 ± 1.4*	26.6 ± 1.0
	OVE26	20.7 ± 1.0	24.2 ± 1.0	29.4 ± 0.9*†	25.9 ± 0.8
Kidney weight (g)	FVB	0.32 ± 0.01	0.40 ± 0.02	0.33 ± 0.01	0.35 ± 0.03
	OVE26	0.38 ± 0.01	0.58 ± 0.04*‡	0.65 ± 0.03*†‡	0.62 ± 0.03*†‡
Kidney/body weight (%)	FVB	1.45 ± 0.04	1.58 ± 0.05	1.23 ± 0.05†	1.31 ± 0.06†
	OVE26	1.78 ± 0.85‡	2.40 ± 0.15*‡	2.22 ± 0.06*‡	2.38 ± 0.06*‡
Urine (μl/min)	FVB	1.58 ± 0.12	2.06 ± 0.12	1.74 ± 0.10	2.26 ± 0.16
	OVE26	2.25 ± 0.13	3.43 ± 0.40‡	5.30 ± 0.73‡	3.47 ± 0.36‡
Blood pressure (mmHg)	FVB	89.7 ± 2.5	91.3 ± 3.0	97.6 ± 2.1	100.3 ± 2.1
	OVE26	81.4 ± 3.2	78.9 ± 2.0‡	77.5 ± 2.6‡	77.1 ± 2.0‡
Hematocrit (%)	FVB	45.3 ± 1.1	44.3 ± 0.8	46.1 ± 0.8	45.5 ± 0.8
	OVE26	47.4 ± 0.9	46.9 ± 0.6	46.9 ± 1.3	44.4 ± 0.8
GFR (μl/min)	FVB	509.9 ± 23.2	603.9 ± 30.0	541.3 ± 31.1	514.3 ± 28.1
	OVE26	506.3 ± 19.3	667.2 ± 26.5*	572.6 ± 26.5	428.3 ± 27.3†‡§
Effective renal plasma flow (μl/min)	FVB	1,121.1 ± 123.7	1,468.1 ± 122.8	1,654.9 ± 218.5	1,378.7 ± 172.7
Effective renal plasma flow (μl/min)		OVE26	1,255.02 ± 135.5	1,205.4 ± 176.8	1,912.2 ± 328.1†	1,132.0 ± 100.9§
Effective renal blood flow (μl/min)	FVB	2,047.5 ± 243.3	2,886.2 ± 358.9	3,049.4 ± 394.6	2,280.6 ± 146.4
Effective renal blood flow (μl/min)		OVE26	2,394.8 ± 269.3	2,880.9 ± 206.7	3,412.8 ± 591.9	2,035.2 ± 193.3§
Filtration fraction	FVB	0.47 ± 0.05	0.43 ± 0.05	0.36 ± 0.04	0.43 ± 0.05
	OVE26	0.46 ± 0.07	0.56 ± 0.08	0.30 ± 0.04	0.39 ± 0.02
Renal vascular resistance (mmHg · ml⁻¹ · min⁻¹)	FVB	14.94 ± 2.55	14.17 ± 1.35	11.79 ± 1.35	15.46 ± 0.69
Renal vascular resistance (mmHg · ml⁻¹ · min⁻¹)		OVE26	14.48 ± 2.15	21.04 ± 3.00‡	18.59 ± 2.61‡	25.59 ± 2.19*‡§

Data are means ± SE. P < 0.05
*
* vs. 2 months,
†
† vs. 3 months,
‡
‡ OVE26 vs. FVB at the same age, and
§
§ vs. 5 months. Determinations for these values are described in research design and methods.