TABLE 2

Kidney hemodynamic and filtration function data obtained from FITC inulin and PAH clearance assays

2 months3 months5 months9 months
n4869
Body weight (g)FVB22.0 ± 0.224.9 ± 1.227.5 ± 1.4*26.6 ± 1.0
OVE2620.7 ± 1.024.2 ± 1.029.4 ± 0.9*25.9 ± 0.8
Kidney weight (g)FVB0.32 ± 0.010.40 ± 0.020.33 ± 0.010.35 ± 0.03
OVE260.38 ± 0.010.58 ± 0.04*0.65 ± 0.03*0.62 ± 0.03*
Kidney/body weight (%)FVB1.45 ± 0.041.58 ± 0.051.23 ± 0.051.31 ± 0.06
OVE261.78 ± 0.852.40 ± 0.15*2.22 ± 0.06*2.38 ± 0.06*
Urine (μl/min)FVB1.58 ± 0.122.06 ± 0.121.74 ± 0.102.26 ± 0.16
OVE262.25 ± 0.133.43 ± 0.405.30 ± 0.733.47 ± 0.36
Blood pressure (mmHg)FVB89.7 ± 2.591.3 ± 3.097.6 ± 2.1100.3 ± 2.1
OVE2681.4 ± 3.278.9 ± 2.077.5 ± 2.677.1 ± 2.0
Hematocrit (%)FVB45.3 ± 1.144.3 ± 0.846.1 ± 0.845.5 ± 0.8
OVE2647.4 ± 0.946.9 ± 0.646.9 ± 1.344.4 ± 0.8
GFR (μl/min)FVB509.9 ± 23.2603.9 ± 30.0541.3 ± 31.1514.3 ± 28.1
OVE26506.3 ± 19.3667.2 ± 26.5*572.6 ± 26.5428.3 ± 27.3§
Effective renal plasma flow (μl/min)FVB1,121.1 ± 123.71,468.1 ± 122.81,654.9 ± 218.51,378.7 ± 172.7
OVE261,255.02 ± 135.51,205.4 ± 176.81,912.2 ± 328.11,132.0 ± 100.9§
Effective renal blood flow (μl/min)FVB2,047.5 ± 243.32,886.2 ± 358.93,049.4 ± 394.62,280.6 ± 146.4
OVE262,394.8 ± 269.32,880.9 ± 206.73,412.8 ± 591.92,035.2 ± 193.3§
Filtration fractionFVB0.47 ± 0.050.43 ± 0.050.36 ± 0.040.43 ± 0.05
OVE260.46 ± 0.070.56 ± 0.080.30 ± 0.040.39 ± 0.02
Renal vascular resistance (mmHg · ml−1 · min−1)FVB14.94 ± 2.5514.17 ± 1.3511.79 ± 1.3515.46 ± 0.69
OVE2614.48 ± 2.1521.04 ± 3.0018.59 ± 2.6125.59 ± 2.19*§
  • Data are means ± SE. P < 0.05

  • *

    * vs. 2 months,

  • vs. 3 months,

  • OVE26 vs. FVB at the same age, and

  • §

    § vs. 5 months. Determinations for these values are described in research design and methods.