TABLE 1

Metabolic measurements of Irs2−/−::Ptp1b−/− intercross mice

GenotypeFasting blood glucose (mg/dl)
Fed blood glucose (mg/dl)
Fasting serum insulin (ng/ml)
Fed serum insulin (ng/ml)
6 weeks15 weeks6 weeks15 weeks6 weeks15 weeks6 weeks15 weeks
Wild type74 ± 479 ± 4155 ± 5140 ± 1170 ± 48475 ± 1601,671 ± 2252,440 ± 277
Ptp1b−/−73 ± 462 ± 5139 ± 6140 ± 681 ± 57280 ± 1301,460 ± 3081,956 ± 400
Irs2−/−169 ± 29369 ± 68434 ± 43440 ± 72631 ± 222476 ± 1011,373 ± 3011,709 ± 644
Irs2−/−::Ptp1b−/−101 ± 8163 ± 61185 ± 17294 ± 82529 ± 213651 ± 3202,340 ± 7482,826 ± 1,167
  • Results represent the mean ± SE of 6–10 mice per genotype.