TABLE 1

Effects of PAI-1 deficiency on lipid content at baseline and 12 weeks after an HF diet

WT + NCPAI-1–/– + NCWT + HFPAI-1–/– + HF
Muscle TG content (mg/g tissue)6.9 ± 1.93.0 ± 1.119.3 ± 3.411.3 ± 2.4*
Liver TG content (mg/g tissue)6.6 ± 1.54.1 ± 0.429.3 ± 4.88.1 ± 2.3*
Serum G content (mg/dl)97.5 ± 4.386.3 ± 6.087.8 ± 7.083.8 ± 6.0
  • Data are means ± SE.

  • *

    * P < 0.05, PAI-1–/– + HF vs. WT + HF (n = 8–10 in each group). NC, normal chow; TG, triglyceride.