TABLE 5

Type 1 diabetes risk in autoantibody-positive relatives: multivariate analysis

Islet autoantibody characteristics significant in univariate analysisnType 1 diabetes (n)Adjusted HR (95% CI)P
Two or more antibodies80371.6 (0.6–3.8)0.32
IA-2A high titer47305.4 (1–29)0.05
IAA high titer18121.0 (0.4–2.7)0.97
IA-2A subclass29223.3 (1.4–8.1)0.008
IAA subclass39194.6 (1.5–14)0.007
Multiple IA-2A epitopes34221.2 (0.5–3)0.70
IA-2β antibody positive30221.1 (0.4–3.2)0.83