Type 1 diabetes risk in autoantibody-positive relatives: multivariate analysis
| Islet autoantibody characteristics significant in univariate analysis | n | Type 1 diabetes (n) | Adjusted HR (95% CI) | P |
|---|---|---|---|---|
| Two or more antibodies | 80 | 37 | 1.6 (0.6–3.8) | 0.32 |
| IA-2A high titer | 47 | 30 | 5.4 (1–29) | 0.05 |
| IAA high titer | 18 | 12 | 1.0 (0.4–2.7) | 0.97 |
| IA-2A subclass | 29 | 22 | 3.3 (1.4–8.1) | 0.008 |
| IAA subclass | 39 | 19 | 4.6 (1.5–14) | 0.007 |
| Multiple IA-2A epitopes | 34 | 22 | 1.2 (0.5–3) | 0.70 |
| IA-2β antibody positive | 30 | 22 | 1.1 (0.4–3.2) | 0.83 |