TABLE 1

Effect of 3-week treatment with GR-ASO on diabetic end points in db/db mice

Serum glucose (mmol/l)Serum triglyceride (mg/dl)Serum FFA (mmol/l)Plasma insulin (pmol/l)Plasma glucagon (ng/l)Body weight gain (g)
Control ASO31.7 ± 2.1455 ± 491.07 ± 0.102,650 ± 600130 ± 107.0 ± 0.6
GR-ASO24.1 ± 2.8*174 ± 140.69 ± 0.056,167 ± 6331,411 ± 1577.0 ± 1.0
  • Data are means ± SE, with n = 12 for each group. Diabetic mice received a 3-week treatment with either control ASO or GR-ASO. Blood samples were collected at the end of study from mice in the fed state biochemical parameters were analyzed as described in research design and methods.

  • *

    * P < 0.05,

  • P < 0.01 compared with the same parameter in the control ASO–treated group.