TABLE 2

Metabolic characteristics during hyperglycemia clamp study

3-month-old9-month-old20-month-old20-month-old VF−20-month-old CR
n66966
Glucose (mmol/l)
  70–120 min11.0 ± 0.311.2 ± 0.111.1 ± 0.310.9 ± 0.211.3 ± 0.2
  190–240 min11.1 ± 0.210.9 ± 0.211.0 ± 0.111.1 ± 0.311.1 ± 0.3
Insulin (ng/ml)
  70–120 min7.9 ± 1.0*12.3 ± 1.115.1 ± 2.011.7 ± 0.68.3 ± 1.0*
  190–240 min27.8 ± 2.434.9 ± 1.827.4 ± 2.323.2 ± 3.413.5 ± 1.7
FFAs (mmol/l)
  70–120 min0.50 ± 0.1*0.73 ± 0.10.72 ± 0.10.70 ± 0.10.45 ± 0.1*
  190–240 min0.48 ± 0.1*0.62 ± 0.10.77 ± 0.10.67 ± 0.10.30 ± 0.1*
Si hyper clamp
  70–120 min5.3 ± 0.5*2.6 ± 0.32.2 ± 0.33.1 ± 0.54.7 ± 0.3*
  190–240 min2.3 ± 0.21.0 ± 0.11.2 ± 0.11.6 ± 0.23.4 ± 0.5*
Glucose infusion rate (mg · kg−1 · min−1)
  70–120 min40.6 ± 5.227.8 ± 2.130.4 ± 2.537.3 ± 5.836.2 ± 3.9
  190–240 min58.6 ± 5.7*34.1 ± 2.530.1 ± 2.137.0 ± 4.246.7 ± 5.5
  • Data are means ± SE.

  • *

    * P < 0.05 vs. 9-month-old, 20-month-old, and 20-month-old VF− rats;

  • P < 0.05 vs. all other groups;

  • P < 0.05 vs. 9-month-old and 20-month-old rats.