TABLE 1

Steady-state values from hyperinsulinemic-euglycemic glucose clamps at various insulin infusions

Insulin infusion rate (mU · kg−1 · min−1)Glucose infusion rate (mg · kg−1 · min−1)Plasma insulin (pmol/l)
Fed
 0 (saline)0337.4 ± 31.4
 12.0 ± 0.3*356.3 ± 42.8
 312.0 ± 0.3*638.1 ± 84.0*
 1022.0 ± 0.9*1,985.4 ± 230.4*
 3025.5 ± 1.2*9,666.5 ± 659.6*
Fasted
 0 (saline)0270.1 ± 46.1
 1.52.6 ± 0.7*425.0 ± 96.9
 37.1 ± 0.7*521.4 ± 50.4*
 1018.4 ± 0.9*1,679.2 ± 130.0*
  • Data are means ± SE.

  • *

    * Significantly different from saline (P < 0.05).