HSL activity and TG content in BAT of cold-exposed mice
| Mouse | Hours at 4°C | HSL (nmol FFA · min−1 · mg protein−1) | TG (mg/IBAT × 10−1) |
|---|---|---|---|
| WT | |||
| 0 | 5.0 ± 0.9 | 2.5 ± 0.5 | |
| 6 | 9.4 ± 1.2 | 3.0 ± 0.3 | |
| 24 | 7.8 ± 1.1 | 1.0 ± 0.2* | |
| Dio2−/− | |||
| 0 | 4.8 ± 0.6 | 3.5 ± 1.0 | |
| 6 | 13.9 ± 2.0* | 1.3 ± 0.4*† | |
| 24 | 15.2 ± 2.6* | 0.5 ± 0.2*† | |
| Hypothyroid | |||
| 0 | 6.3 ± 1.3 | 2.0 ± 0.8 | |
| 6 | 12.4 ± 1.9† | 0.3 ± 0.3*† |
Data are means ± SD of four to five animals.
* P < 0.001 vs. the same time in WT animals;
† P < 0.01 vs. the same time in WT animals by ANOVA. Hypothyroid mice are WT. This experiment was performed twice.