TABLE 3

Magnetic resonance imaging findings in nondiabetic and diabetic subjects

MRI findingNondiabetic subjectsDiabetic subjectsP value
n1,138114
Focal lesions
 Total periventricular WML-score2.0 (1.0–3.0)2.0 (1.0–4.0)0.10*
 Severe periventricular WML (%)18.725.40.08
 Total volume of subcortical WML0.16 (0.02–1.07)0.31 (0.02–1.79)0.18*
 Severe subcortical WML (%)25.729.80.35
 Presence of infarcts (%)7.29.60.34
Measures of brain atrophy
 Total cortical atrophy-score7.2 ± 3.08.2 ± 3.20.001*
 Severe cortical atrophy (%)22.635.10.003
 Subcortical atrophy
  Ventricle-to-brain ratio0.32 ± 0.040.33 ± 0.040.03*
  Severe subcortical atrophy (%)23.829.80.16
  • Data are median (interquartile range) or means±SE, unless otherwise noted.

  • *

    * Mann-Whitney U test,

  • χ2 test. Severe abnormalities were considered if the extent of changes belonged to the upper quintile of the distribution.