TABLE 1

Characteristics of the subjects/patients

ParameterHealthy control subjectsPatients with CRISignificance (P value)*
Anthropometric data
Sex (female/male)4/65/50.65
Age (years)44 ± 1247 ± 150.59
BMI (kg/m2)24.9 ± 3.424.5 ± 2.20.80
Waist-to-hip ratio (cm/cm)0.81 ± 0.090.92 ± 0.050.31
Hematological, metabolic, and lipid parameters
  Hemoglobin (g/dl)14.3 ± 0.4411.9 ± 0.30.00033
  Fasting glucose (mmol/l)5.66 ± 0.565.28 ± 0.720.24
  120-min glucose (mmol/l)6.94 ± 1.06.17 ± 1.330.17
  HbA1c (%)5.9 ± 0.55.6 ± 0.70.38
  HOMAB-cell function (% normal)88 ± 5578 ± 590.70
  HOMAinsulin resistance (fold normal)2.48 ± 2.081.49 ± 1.190.21
  Total cholesterol (mmol/l)5.67 ± 1.375.05 ± 0.730.21
  HDL cholesterol (mmol/l)1.11 ± 0.441.27 ± 0.650.54
  LDL cholesterol (mmol/l)4.144 ± 1.223.21 ± 0.470.039
  Triglycerides (mmol/l)1.85 ± 1.21.49 ± 0.870.46
  Hypertension (yes/no)0/109/1<0.0001
  Blood pressure
    Systolic (mmHg)121 ± 12127 ± 110.25
    Diastolic (mmHg)82 ± 784 ± 40.43
Parameters of kidney function
  Serum creatinine (mg/dl)0.89 ± 0.102.18 ± 0.860.00016
  Serum urea (mg/dl)25.9 ± 3.8684.7 ± 27.7<0.0001
  Creatinine clearance (ml/min)§107 ± 2746 ± 24<0.0001
  Cystatin C (mg/l)0.71 ± 0.131.9 ± 0.46<0.0001
  Albuminuria (mg/day)20.7 ± 46350.2 ± 6020.12
  Proteinuria (mg/day)150 ± 151827 ± 1280.14
  • Data are means ± SD.

  • *

    * ANOVA or χ2 test.

  • 120 min after oral glucose ingestion.

  • Calculated according to (24).

  • §

    § Calculated according to (25).