RR (95% CI) of type 2 diabetes according to quintiles of inflammatory markers estimated from conditional logistic regression models
| Q1 | Q2 | Q3 | Q4 | Q5 | P for trend | |
|---|---|---|---|---|---|---|
| TNFαR2 (pg/ml) | ||||||
| Range | ≤1,927.7 | 1,827.8–2,224.4 | 2,224.5–2,530.0 | 2,530.1–3,023.5 | ≥3,023.6 | |
| Median | 1,705.6 | 2,085.5 | 2,385.9 | 2,737.5 | 3,448.4 | |
| n | 96/167 | 98/155 | 124/153 | 192/155 | 227/155 | |
| Crude RR* | 1.00 | 1.14 (0.79, 1.65) | 1.29 (0.90, 1.84) | 2.10 (1.49, 2.95) | 2.59 (1.84, 3.65) | <0.001 |
| BMI-adjusted RR† | 1.00 | 1.00 (0.68, 1.48) | 1.11 (0.76, 1.62) | 1.56 (1.08, 2.24) | 1.67 (1.16, 2.42) | <0.001 |
| Multivariate RR‡ | 1.00 | 0.89 (0.58, 1.37) | 1.09 (0.73, 1.64) | 1.47 (0.99, 2.18) | 1.64 (1.10, 2.45) | 0.001 |
| IL-6 (pg/ml) | ||||||
| Range | ≤1.12 | 1.13–1.62 | 1.63–2.13 | 2.15–3.07 | ≥3.08 | |
| Median | 0.88 | 1.34 | 1.84 | 2.55 | 4.24 | |
| n | 88/185 | 110/150 | 134/150 | 176/151 | 229/149 | |
| Crude RR | 1.00 | 1.60 (1.11, 2.31) | 1.77 (1.24, 2.53) | 2.44 (1.71, 3.46) | 3.25 (2.30, 4.58) | <0.001 |
| BMI-adjusted RR | 1.00 | 1.29 (0.87, 1.90) | 1.21 (0.83, 1.78) | 1.55 (1.06, 2.26) | 1.95 (1.34, 2.84) | <0.001 |
| Multivariate RR | 1.00 | 1.24 (0.82, 1.88) | 1.23 (0.81, 1.86) | 1.43 (0.95, 2.15) | 1.91 (1.27, 2.86) | 0.001 |
| CRP (mg/dl) | ||||||
| Range | ≤0.055 | 0.056–0.118 | 0.119–0.208 | 0.209–0.404 | ≥0.405 | |
| Median | 0.03 | 0.083 | 0.158 | 0.291 | 0.627 | |
| n | 55/176 | 58/152 | 89/153 | 216/152 | 319/152 | |
| Crude RR | 1.00 | 1.36 (0.87, 2.13) | 2.11 (1.38, 3.22) | 4.93 (3.33, 7.31) | 7.08 (4.84, 10.37) | <0.001 |
| BMI-adjusted RR | 1.00 | 1.20 (0.75, 1.91) | 1.68 (1.08, 2.62) | 3.64 (2.42, 5.49) | 4.18 (2.78, 6.29) | <0.001 |
| Multivariate RR | 1.00 | 1.30 (0.80, 2.13) | 1.62 (1.01, 2.06) | 3.61 (2.33, 5.60) | 4.36 (2.80, 6.80) | <0.001 |
* Conditioned on matching variables: age, fasting status, and race;
† BMI as a continuous variable;
‡ adjusted for time at blood drawn, alcohol consumption (nondrinkers, 0–4.9, 5–10, and >10 g/day), physical activity (quintiles of METs/week), smoking status (never, past, and current smoking of 1–14, 15–24, and ≥25 cigarettes per day), BMI (continuous), family history of diabetes, postmenopausal hormone use and menopausal status (never/unknown user or premenopausal status, past, and current user), and diet score (in quintiles).