TABLE 3

RR (95% CI) of type 2 diabetes according to quintiles of inflammatory markers estimated from conditional logistic regression models

Q1Q2Q3Q4Q5P for trend
TNFαR2 (pg/ml)
 Range≤1,927.71,827.8–2,224.42,224.5–2,530.02,530.1–3,023.5≥3,023.6
 Median1,705.62,085.52,385.92,737.53,448.4
n96/16798/155124/153192/155227/155
 Crude RR*1.001.14 (0.79, 1.65)1.29 (0.90, 1.84)2.10 (1.49, 2.95)2.59 (1.84, 3.65)<0.001
 BMI-adjusted RR1.001.00 (0.68, 1.48)1.11 (0.76, 1.62)1.56 (1.08, 2.24)1.67 (1.16, 2.42)<0.001
 Multivariate RR1.000.89 (0.58, 1.37)1.09 (0.73, 1.64)1.47 (0.99, 2.18)1.64 (1.10, 2.45)0.001
IL-6 (pg/ml)
 Range≤1.121.13–1.621.63–2.132.15–3.07≥3.08
 Median0.881.341.842.554.24
n88/185110/150134/150176/151229/149
 Crude RR1.001.60 (1.11, 2.31)1.77 (1.24, 2.53)2.44 (1.71, 3.46)3.25 (2.30, 4.58)<0.001
 BMI-adjusted RR1.001.29 (0.87, 1.90)1.21 (0.83, 1.78)1.55 (1.06, 2.26)1.95 (1.34, 2.84)<0.001
 Multivariate RR1.001.24 (0.82, 1.88)1.23 (0.81, 1.86)1.43 (0.95, 2.15)1.91 (1.27, 2.86)0.001
CRP (mg/dl)
 Range≤0.0550.056–0.1180.119–0.2080.209–0.404≥0.405
 Median0.030.0830.1580.2910.627
n55/17658/15289/153216/152319/152
 Crude RR1.001.36 (0.87, 2.13)2.11 (1.38, 3.22)4.93 (3.33, 7.31)7.08 (4.84, 10.37)<0.001
 BMI-adjusted RR1.001.20 (0.75, 1.91)1.68 (1.08, 2.62)3.64 (2.42, 5.49)4.18 (2.78, 6.29)<0.001
 Multivariate RR1.001.30 (0.80, 2.13)1.62 (1.01, 2.06)3.61 (2.33, 5.60)4.36 (2.80, 6.80)<0.001
  • *

    * Conditioned on matching variables: age, fasting status, and race;

  • BMI as a continuous variable;

  • adjusted for time at blood drawn, alcohol consumption (nondrinkers, 0–4.9, 5–10, and >10 g/day), physical activity (quintiles of METs/week), smoking status (never, past, and current smoking of 1–14, 15–24, and ≥25 cigarettes per day), BMI (continuous), family history of diabetes, postmenopausal hormone use and menopausal status (never/unknown user or premenopausal status, past, and current user), and diet score (in quintiles).