TABLE 4

Multivariate RR (95% CI) of type 2 diabetes according to quintiles of inflammatory markers stratified by BMI, physical activity, diet score, and family history of diabetes*

Q1Q2Q3Q4Q5P for trendP for interaction
TNFαR2
 BMI <30 kg/m21.000.95 (0.58–1.57)1.16 (0.72–1.87)1.62 (1.02–2.59)2.25 (1.39–3.62)<0.001
 BMI ≥30 kg/m21.000.67 (0.26–1.68)1.33 (0.53–3.35)1.05 (0.45–2.44)0.93 (0.41–2.09)0.990.01
 Physical activity levels
  Low1.001.02 (0.58–1.77)1.74 (1.02–2.98)1.96 (1.18–3.28)2.14 (1.29–3.54)<0.001
  High1.000.75 (0.41–1.38)0.86 (0.48–1.54)1.29 (0.74–2.26)1.30 (0.72–2.34)0.110.72
 Diet score
  Low1.000.74 (0.42–1.29)1.04 (0.61–1.76)1.45 (0.89–2.36)2.05 (1.25–3.36)<0.001
  High1.001.06 (0.58–1.94)1.32 (0.73–2.38)1.78 (0.98–3.23)1.18 (0.64–2.18)0.480.21
 Family history of diabetes
  Yes1.000.73 (0.38–1.39)0.75 (0.38–1.45)1.15 (0.60–2.19)1.51 (0.75–3.07)0.07
  No1.000.93 (0.54–1.62)1.45 (0.87–2.41)1.82 (1.12–2.96)1.88 (1.16–3.04)0.0020.46
IL-6
 BMI <30 kg/m21.001.20 (0.75–1.92)1.14 (0.70–1.84)1.44 (0.90–2.30)1.84 (1.16–2.94)0.006
 BMI ≥30 kg/m21.000.90 (0.31–2.62)1.11 (0.41–3.00)1.07 (0.41–2.78)1.46 (0.57–3.76)0.170.29
 Physical activity levels
  Low1.001.31 (0.75–2.29)1.27 (0.73–2.23)1.70 (1.00–2.91)2.47 (1.44–4.24)<0.001
  High1.001.38 (0.77–2.45)1.63 (0.93–2.86)1.44 (0.81–2.53)1.77 (1.01–3.08)0.090.73
 Diet score
  Low1.000.96 (0.56–1.65)1.36 (0.80–2.29)1.30 (0.78–2.16)1.86 (1.12–3.09)0.004
  High1.001.74 (0.96–3.15)1.28 (0.69–2.36)1.85 (1.01–3.37)2.16 (1.19–3.92)0.0240.38
 Family history of diabetes
  Yes1.001.99 (1.02–3.88)1.79 (0.90–3.55)2.19 (1.14–4.20)1.97 (1.04–3.73)0.16
  No1.000.90 (0.54–1.50)1.15 (0.70–1.87)1.29 (0.80–2.10)1.95 (1.21–3.13)<0.0010.13
CRP
 BMI <30 kg/m21.000.80 (0.46–1.37)0.98 (0.57–1.69)2.42 (1.49–3.95)3.57 (2.13–5.96)<0.001
 BMI ≥30 kg/m21.001.74 (0.48–6.27)1.42 (0.49–4.18)2.76 (1.01–7.58)3.38 (1.31–8.77)0.0040.13
 Physical activity levels
  Low1.001.28 (0.69–2.37)1.51 (0.83–2.74)3.71 (2.14–6.43)4.28 (2.47–7.43)<0.001
  High1.000.86 (0.42–1.78)1.34 (0.68–2.62)2.81 (1.49–5.30)4.01 (2.09–7.68)<0.0010.87
 Diet score
  Low1.001.03 (0.55–1.92)1.28 (0.72–2.27)2.91 (1.70–5.01)4.33 (2.50–7.49)<0.001
  High1.001.23 (0.61–2.49)1.69 (0.83–3.46)3.89 (2.05–7.36)4.10 (2.13–7.88)<0.0010.94
 Family history of diabetes
  Yes1.001.49 (0.66–3.36)1.84 (0.89–3.79)3.27 (1.61–6.61)3.73 (1.85–7.56)<0.001
  No1.000.94 (0.51–1.72)1.15 (0.64–2.11)3.30 (1.97–5.52)4.66 (2.74–7.89)<0.0010.15
  • *

    * Physical activity and diet score were classified into low and high groups according to median values. RRs were adjusted for the same variables as in table 3.