TABLE 5

Multipoint results after the fine-mapping step

ChromosomeFine-mapping interval (cM)Average densityTraitMLB LOD (P)*MLS LOD (P)*1-LOD unit (CI) (cM)Location (cM)
2q33.2-q36.3D2S112-D2S3963.84PCT992.73 (0.0002)3.05 (0.0002)22.34 (214.96–237.30)230.62
PCT972.08 (0.001)2.33 (0.001)24.46 (214.00–238.46)230.62
6q22.31-q23.2D6S462-D6S4413.01PCT973.27 (0.00005)4.06 (0.00002)10.85 (125.97–136.82)129.76
PCT953.13 (0.00007)3.77 (0.00003)11.53 (125.29–136.82)128.95
15q12-q15.1D15S128-D15S1532.22AAR2.53 (0.0003)NA13.67 (21.71–35.38)32.69
16q22.1-q24.1D16S415-D16S5203.13AAR2.54 (0.0003)NA21.68 (95.63–117.31)105.15
17p13D17S849-D17S7991.96PCT952.25 (0.0007)2.35 (0.001)6.50 (16.59–23.09)18.70
19p13.3p13.11D19S221-D19S4142.58AAR2.13 (0.0009)NA22.62 (24.71–47.33)44.60
  • *

    * P: single-test P value. A Genethon map was used. Only the traits with suggestive evidence for linkage are reported here (LOD MLS ≥2.32, LOD MLB ≥2.08, P ≤ 0.001).