TABLE 3

Comparison of the clinical characteristics of affected individuals in the index case generation in FUSION 1 and FUSION 2

TraitFUSION 1FUSION 2P value
Age at clinical examination (years)64.4 ± 8.365.1 ± 8.50.17
Age at diabetes diagnosis (years)52.1 ± 9.053.5 ± 9.80.007
Duration of diabetes (years)12.3 ± 7.411.7 ± 7.80.15
BMI (kg/m2)29.8 ± 4.829.7 ± 4.70.91
Waist-to-hip ratio0.938 ± 0.0790.937 ± 0.0730.16
Fasting plasma glucose (mmol/l)10.4 ± 3.49.1 ± 2.8<0.0001
Fasting plasma insulin (pmol/l)113.7 ± 83.0108.1 ± 84.90.10
Fasting serum C-peptide (nmol/l)1.59 ± 0.982.39 ± 1.50<0.0001
Empirical insulin sensitivity (×103)1.75 ± 3.042.11 ± 3.27<0.0001
Empirical insulin secretion (insulin)11.9 ± 8.912.9 ± 14.20.50
Empirical insulin secretion (C-peptide)0.165 ± 0.1120.273 ± 0.179<0.0001
Serum total cholesterol (mmol/l)5.75 ± 1.205.49 ± 1.020.0008
Serum HDL cholesterol (mmol/l)1.09 ± 0.301.17 ± 0.31<0.0001
Serum LDL cholesterol (mmol/l)3.62 ± 0.973.43 ± 0.850.006
HDL cholesterol–to–total cholesterol ratio0.195 ± 0.0610.219 ± 0.064<0.0001
Serum triglycerides (mmol/l)2.45 ± 2.042.07 ± 1.47<0.0001
Diastolic blood pressure (mmHg)84.4 ± 10.784.9 ± 10.20.46
Systolic blood pressure (mmHg)152.3 ± 22.5152.0 ± 20.70.97
  • Data are means ± SD.