TABLE 2

Results of the genome-wide multipoint NPL analyses of African-American families with type 2 diabetes showing the highest LOD score for each chromosome

Allele-sharing model
NPL regression
ChromosomePosition (cM)Nearest markerLODLOD-1 interval*Single-locus model
Multilocus model
LODLOD-1 intervalLODLOD-1 interval
176.0D1S21340.2762.0–98.50.2562.0–98.5
277.5D2S13520.3866.5–101.00.3566.0–101.0
322.0D3S13040.54pter–48.00.58pter–48.0
4202.5D4S408/D4S16520.82175.0–qter0.80175.0–qter
5139.0D5S8160.36130.0–154.50.37130.0–55.0
6163.5D6S10352.26148.0–174.52.08143.0–179.02.69136.5–qter
729.0D7S30510.75pter–75.50.86pter–75.01.06pter–50.5
843.5D8S1360.2824.5–53.50.2924.5–54.0
9154.0D9S2157/D9S18260.92128.5–qter0.75105.0–qter
10133.0D10S12370.8777.0–qter0.8677.0–qter
1133.0ATA34E080.3025.0–51.50.2925.0–51.5
1256.0GATA91H060.3732.5–67.50.4132.5–67.5
1399.0D13S12650.0896.0–102.50.0796.0–102.5
14111.0D14S14340.5895.5–qter0.7095.5–qter
1571.0D15S1310.1463.0–qter0.1463.0–qter
16129.0D16S26210.81108.0–qter0.87108.0–qter
17124.0D17S9280.25101.5–qter0.24102.0–qter
1886.5D18S8620.5445.0–121.00.5548.0–qter0.8747.5–qter
18115.0D18S13710.949.5–qter0.8749.5–qter
1933.0D19S5860.71pter–qter0.65pter–qter
2041.0D20S4700.21pter–53.50.21pter–53.5
2157.5D21S14460.0950.0–qter0.0950.0–qter
2232.0D22S6851.3321.0–qter1.2820.0–qter
  • *

    * LOD-1 interval for LOD scores <1.0 represents contiguous portions of the chromosome that have positive evidence for linkage. pter, p-terminus; qter, q-terminus.