TABLE 2

Association of VEGF −460 genotype with proliferative diabetic retinopathy in patients with diabetes

GenotypeTTCTCCCT or CC
Analysis by −460 genotype
 Proliferative retinopathy10 (14)43 (62)16 (23)
 Nonproliferative retinopathy or no retinopathy59 (30)92 (46)47 (24)
P = 0.027
 Control subjects (n = 23)28%50%22%
 Odds ratio (95% CI)12.76 (1.29–5.90)2.01 (0.83–4.83)
Analysis by carriage of −460C
 Proliferative retinopathy10 (14)59 (86)
 Nonproliferative retinopathy59 (30)139 (70)
P = 0.016
 Odds ratio (95% CI)12.50 (1.20–5.23)
Analysis by type of diabetes: carriage of −460C
 Type 1 diabetes
 Proliferative retinopathy7 (14)42 (86)
 Nonproliferative retinopathy33 (27)90 (73)
P = 0.06
 Odds ratio (95% CI)12.2 (0.9–5.4)
 Type 2 diabetes
 Proliferative retinopathy3 (15)17 (85)
 Nonproliferative retinopathy25 (35)47 (65)
P = 0.07
 Odds ratio (95% CI)13.0 (0.8–11.3)
  • Data are n (%) unless otherwise indicated.