TABLE 1

Final body weights and blood glucose concentrations in experimental mice and rats

Body weight (g)
Blood glucose (mmol/l)
Initial*Final
Mouse
 STZ-induced diabetes model
  PARP+/+25.4 ± 0.727.8 ± 0.77.03 ± 0.43
  PARP+/+ diab25.8 ± 0.524.5 ± 0.8§22.7 ± 0.48
  PARP−/−24.0 ± 0.427.2 ± 0.85.72 ± 0.27
  PARP−/− diab25.4 ± 0.423.2 ± 0.923.4 ± 0.86
 Galactose-fed model
  PARP+/+24.2 ± 0.625.6 ± 0.76.55 ± 0.15
  PARP+/+ gal25.8 ± 0.825.1 ± 0.97.72 ± 0.12
  PARP−/−23.8 ± 0.526.1 ± 0.56.45 ± 0.24
  PARP−/− gal26.0 ± 0.725.7 ± 0.76.43 ± 0.39
Rat
 Control289 ± 4462 ± 74.27 ± 0.17
 Control + ABA295 ± 4416 ± 10§4.22 ± 0.33
 Control + ISO286 ± 5449 ± 113.88 ± 0.33
 Diabetic285 ± 4390 ± 2420.4 ± 1.44
 Diabetic + ABA279 ± 5343 ± 920.1 ± 0.50
 Diabetic + ISO281 ± 3363 ± 820.8 ± 0.39
  • *

    * Data are means ± SE, n = 30–32. Before induction of STZ-induced diabetes;

  • significantly different from controls (P < 0.01, respectively);

  • significantly different from untreated diabetic group (P < 0.01).

  • §

    § Significantly different from controls (P < 0.05).