TABLE 3

Nerve energy state in the mouse and rat models

PCr (μmol/g)PCr/Cr
Mouse
 STZ-induced diabetes model
  PARP+/+0.852 ± 0.0570.161 ± 0.012
  PARP+/+ diab0.347 ± 0.0370.063 ± 0.013
  PARP−/−0.832 ± 0.0920.140 ± 0.013
  PARP−/− diab0.873 ± 0.0970.153 ± 0.027
 Study in galactose-fed model
  PARP+/+0.869 ± 0.0320.206 ± 0.023
  PARP+/+ gal0.481 ± 0.082*0.105 ± 0.006*
  PARP−/−0.829 ± 0.0940.209 ± 0.023
  PARP−/− gal0.753 ± 0.1370.185 ± 0.029
Rat
 Control3.45 ± 0.220.898 ± 0.053
 Control + ABA3.03 ± 0.250.755 ± 0.033
 Control + ISO3.34 ± 0.180.725 ± 0.057
 Diabetic2.36 ± 0.140.553 ± 0.043
 Diabetic + ABA3.30 ± 0.180.697 ± 0.030*
 Diabetic + ISO3.48 ± 0.10§0.786 ± 0.012
  • Data are means ± SE, n = 6–8.

  • *

    * P < 0.05 and

  • P < 0.01 compared with controls;

  • P < 0.05 and

  • §

    § P < 0.01 compared with the untreated diabetic group.