TABLE 1

Effect of the GABAA receptor antagonist SR95531 on hormone release from isolated rat islets

Glucose (mmol/l)Insulin (ng · islet−1 · h−1)
Somatostatin (pmol · islet−1 · h−1)
Glucagon (pg · islet−1 · h−1)
120120120
Control0.37 ± 0.036.17 ± 0.35.05 ± 0.524.48 ± 1.127.18 ± 2.115.31 ± 1.2
10 μmol/l SR955310.32 ± 0.066.01 ± 0.25.50 ± 0.226.1 ± 1.646.72 ± 3.8*51.04 ± 4.0*
  • Data are means ± SE of 10 experiments.

  • *

    * P < 0.001 vs. control;

  • NS vs. 10 μmol/l SR95531 at 1 mmol/l glucose.