TABLE 2

Effect of Ca²⁺ channel antagonists on hormone release from rat islets

Glucose (mmol/l)	Insulin (ng · islet⁻¹ · h⁻¹)			Somatostatin (pmol · islet⁻¹ · h⁻¹)			Glucagon (pg · islet⁻¹ · h⁻¹)
Glucose (mmol/l)		1	20	1	20	1	20
Control	0.49 ± 0.04	10.39 ± 0.7	4.30 ± 0.6	17.82 ± 2.3	36.85 ± 2.3	19.79 ± 1.2
2.5 μmol/l isradipine	0.47 ± 0.05	1.72 ± 0.2*	3.65 ± 0.5	14.06 ± 1.3	34.10 ± 2.5‡	28.98 ± 3.6§
0.1 μmol/l SNX482	0.42 ± 0.04	8.87 ± 0.9	2.92 ± 0.3	9.37 ± 1.3†	39.75 ± 3.9	23.91 ± 3.3
0.1 μmol/l ω-conotoxin GVIA	0.44 ± 0.04	9.40 ± 0.6	3.44 ± 0.5	14.13 ± 2.6	17.03 ± 2.9*	16.06 ± 1.1

Data are means ± SE of 8 experiments. Hormone release was measured at 1 and 20 mmol/l glucose in the absence and presence of isradipine, SNX482, and ω-conoxotin GVIA as indicated. Statistical significance is evaluated against the control at the same glucose concentration.
*
* P < 0.001;
†
† P < 0.01;
‡
‡ NS;
§
§ P < 0.05.