TABLE 2

Effect of Ca2+ channel antagonists on hormone release from rat islets

Glucose (mmol/l)Insulin (ng · islet−1 · h−1)
Somatostatin (pmol · islet−1 · h−1)
Glucagon (pg · islet−1 · h−1)
120120120
Control0.49 ± 0.0410.39 ± 0.74.30 ± 0.617.82 ± 2.336.85 ± 2.319.79 ± 1.2
2.5 μmol/l isradipine0.47 ± 0.051.72 ± 0.2*3.65 ± 0.514.06 ± 1.334.10 ± 2.528.98 ± 3.6§
0.1 μmol/l SNX4820.42 ± 0.048.87 ± 0.92.92 ± 0.39.37 ± 1.339.75 ± 3.923.91 ± 3.3
0.1 μmol/l ω-conotoxin GVIA0.44 ± 0.049.40 ± 0.63.44 ± 0.514.13 ± 2.617.03 ± 2.9*16.06 ± 1.1
  • Data are means ± SE of 8 experiments. Hormone release was measured at 1 and 20 mmol/l glucose in the absence and presence of isradipine, SNX482, and ω-conoxotin GVIA as indicated. Statistical significance is evaluated against the control at the same glucose concentration.

  • *

    * P < 0.001;

  • P < 0.01;

  • NS;

  • §

    § P < 0.05.