TABLE 1

Phenotypic characterization of experimental animals

GenotypenAge (weeks)DietGlucose (mg/dl)Albuminuria (μg/24 h)Mesangial matrix scoreBody weight (g)Kidney weight (mg)
db/m816Normal151 ± 123.6 ± 1.7122.7 ± 0.2164 ± 4
db/m1524Normal161 ± 127.6 ± 2.51.5 ± 0.130 ± 0.5216 ± 5
db/m1024High protein135 ± 1710.4 ± 21.2 ± 0.129.9 ± 0.7226 ± 12
db/db616Normal557 ± 23*78 ± 302.1 ± 0.3*45.7 ± 1*219 ± 7*
db/db1024Normal543 ± 37*68 ± 15*3.8 ± 0.1*48.1 ± 2*228 ± 5
db/db3024High protein531 ± 13*206 ± 36*3.2 ± 0.1*45 ± 0.8*241 ± 6
C57BL/6J control524Normal233 ± 4.525 ± 0.7121.2 ± 0.7138 ± 7
C57BL/6J STZ824Normal516 ± 36*69 ± 8*2*20.8 ± 0.5197 ± 10
129 SvJ control530Normal111 ± 434 ± 122.5 ± 0.226 ± 0.6221 ± 11
129 SvJ STZ830Normal512 ± 27*65 ± 73.1 ± 0.323 ± 0.6232 ± 8
  • Data are means ± SE. Bold face groups were included in microarray analysis.

  • *

    * P < 0.01 and

  • P < 0.05 compared with corresponding controls.