TABLE 3

Phenotype associations with rs2144908 in unaffected offspring under recessive, dominant, additive, and general (2 degrees of freedom) genetic models.

AAAGGGP value*
RecessiveDominantAdditive2 df
n14141316
BMI (kg/m2)22.9 (4.0)25.1 (5.1)25.6 (5.7)0.0070.3580.0910.021
Fasting glucose (mmol/l)4.96 (0.30)5.02 (0.52)4.97 (0.67)0.8120.1420.1330.322
2-h glucose (mmol/l)5.72 (1.53)5.25 (1.74)5.11 (1.86)0.0250.0500.0170.029
Δ Glucose (mmol/l)0.81 (1.26)0.28 (1.80)0.05 (1.82)0.0290.0550.0190.036
Fasting insulin (pmol/l)69.0 (30.0)60.0 (42.0)60.0 (42.0)0.0130.4260.9830.020
2-h insulin (pmol/l)345 (432)228 (330)231 (288)0.0100.4410.1390.037
Δ Insulin (pmol/l)276 (426)174 (276)168 (270)0.0190.3710.1220.062
Insulin sensitivity (10−5 · min−1 · pmol−1 · l)8.6 (8.18)6.13 (5.07)6.87 (6.02)0.6840.3190.3950.555
AIRg (10−2 · pmol · l−1 · 8 min)§1.74 (1.88)1.74 (1.90)1.89 (1.86)0.4030.0090.0230.022
Disposition index (×10−3)11.6 (13.6)10.7 (11.7)12.5 (10.9)0.5830.0030.0080.007
  • Data are unadjusted median values (interquartile range).

  • *

    * P values calculated for age- and sex-adjusted data and, for traits not involving weight, also for BMI-adjusted data; P values <0.05 are in boldface;

  • difference between 2-h and fasting values;

  • derived from minimal model analysis of frequently sampled intravenous glucose tolerance tests;

  • §

    § computed from the frequently sampled intravenous glucose tolerance test as the incremental area under the insulin curve from 0 to 10 min;

  • product of insulin sensitivity and AIRg, a measure of β-cell function. AIRg, acute insulin response to glucose.