TABLE 2

G-11391A genotype frequencies, according to glycemic status after 3 years in subjects who were normoglycemic at baseline, and ORs (95% CI) for hyperglycemia: the DESIR study

Genotype*GG
GA
AA
n%n%n%
Normoglycemic (fasting glucose <6.1 mmol/l)3,07282.462016.6340.9
IFG (fasting glucose 6.1–7 mmol/l)15075.44824.110.5
Type 2 diabetes (fasting glucose ≥7 mmol/l or treated for diabetes)2580.6619.400.0
Hyperglycemia (IFG plus type 2 diabetes)17576.15423.510.4
OR (95% CI) for hyperglycemia (adjusted for sex)11.60 (1.16–2.20), P = 0.0040.55 (0.07–4.04), P = 0.554
OR A+: 1.55 (1.13–2.12), P = 0.007
OR (95% CI) for hyperglycemia (adjusted for sex, age, BMI, WHR, insulin, glucose, and change in body weight and WHR)11.65 (1.17–2.32), P = 0.0040.59 (0.08–4.54), P = 0.613
OR A+: 1.59 (1.13–2.23), P = 0.008
  • *

    * Genotype frequencies differ according to classes: normoglycemia and hyperglycemia: Pearson χ2 = 7.573 for df = 2, P = 0.023; normoglycemia, impaired fasting glycemia, and diabetes: Pearson χ2 = 8.097 for df = 4, P = 0.088;

  • by logistic regression (reference = frequent GG genotype).