TABLE 3

T45G genotype frequencies, according to glycemic status after 3 years in subjects who were normoglycemic at baseline, and ORs (95% CI) for hyperglycemia: the DESIR study

Genotype*TT
TG
GG
n%n%n%
Normoglycemic (fasting glucose <6.1 mmol/l)2,81675.784722.8561.5
IFG (fasting glucose 6.1–7 mmol/l)14070.75025.384.0
Type 2 diabetes (fasting glucose ≥7 mmol/l or treated for diabetes)2477.4619.413.2
Hyperglycemia (IFG plus type 2 diabetes)16471.65624.593.9
OR (95% CI) for hyperglycemia (adjusted for sex)11.13 (0.83–1.55), P = 0.4482.71 (1.31–5.60), P = 0.007
OR (95% CI) for hyperglycemia (adjusted for sex, age, BMI, WHR, insulin, glucose, and change in body weight and WHR)11.06 (0.76–1.49), P = 0.7122.88 (1.29–6.46), P = 0.010
  • *

    * Genotype frequencies differ according to classes: normoglycemia and hyperglycemia: Pearson χ2 = 8.448 for df = 2, P = 0.015; normoglycemia, impaired fasting glycemia, and diabetes: Pearson χ2 = 9.124 for df = 4, P = 0.058;

  • by logistic regression (reference = frequent and TT genotype).