TABLE 1

Twenty-four-hour profiles and fasting values

LiraglutidePlaceboP
Fasting values
 Plasma glucose (mmol/l)8.06 ± 0.529.39 ± 0.760.078
 Plasma glucose day 9 (mmol/l)7.56 ± 0.429.20 ± 0.780.025
 FFA (mmol/l)0.52 ± 0.030.51 ± 0.030.536
 Insulin (pmol/l)95.6 ± 15.187.2 ± 17.90.513
 ISR (nmol/h)17.7 ± 2.016.1 ± 2.10.206
 Proinsulin/insulin ratio0.17 ± 0.040.27 ± 0.050.009
 Glucagon (pg/ml)92.8 ± 7.294.5 ± 5.60.586
24-h total AUCs
 Plasma glucose (mmol · l−1 · h)187.5 ± 14.0232.3 ± 21.90.014
 FFA (mmol · l−1 · h)8.54 ± 0.518.65 ± 0.680.876
 Insulin (pmol · l−1 · h)3,854 ± 5814,154 ± 8810.375
 ISR (nmol)566.1 ± 55.1561.6 ± 72.60.982
 Glucagon (pg · ml−1 · h)2,179 ± 1182,371 ± 1350.037
Postprandial total AUCs
 Plasma glucose 8–12 h (mmol · l−1 · h)38.66 ± 3.5247.51 ± 3.950.010
 Plasma glucose 12–16 h (mmol · l−1 · h)32.52 ± 2.9241.89 ± 4.540.017
 Plasma glucose 18–22 h (mmol · l−1 · h)33.76 ± 2.5041.10 ± 3.940.016
 Insulin 8–12 h (pmol · l−1 · h)999 ± 1731,056 ± 2530.512
 Insulin 12–16 h (pmol · l−1 · h)723 ± 107808 ± 1620.312
 Insulin 18–22 h (pmol · l−1 · h)1,017 ± 1601,117 ± 2210.392
 Proinsulin/insulin ratio 8–12 h0.12 ± 0.030.19 ± 0.040.008
 Glucagon 8–12 h (pg · ml−1 · h)383.0 ± 22.8413.4 ± 25.60.080
 Glucagon 12–16 h (pg · ml−1 · h)362.6 ± 18.6374.2 ± 19.50.384
 Glucagon 18–22 h (pg · ml−1 · h)397.3 ± 23.9470.1 ± 35.20.009
  • Data are means ± SEM. Twenty-four-hour AUCs were calculated from samples obtained from 0800 to 0800. Fasting values were calculated from samples taken at 0730 and 0800 on days 8 and 9.