TABLE 3

Association of Kir6.2 haplotypes with type 2 diabetes

HaplotypeORP95% CIFrequency
A0.870.020.77–0.990.27
B1.090.070.97–1.230.26
C0.910.110.78–1.060.16
D1.040.650.84–1.300.06
E1.260.030.99–1.600.05
F0.960.370.74–1.230.05
G1.230.090.91–1.660.03
H1.100.330.73–1.640.02
M1.000.500.52–1.930.01
B+D+E1.150.011.03–1.290.38
  • Haplotypes of >2% frequency were tested for association with type 2 diabetes in our patient samples and analyzed by Mantel-Haenszel meta-analysis as above. Together, they compose 91% of the haplotypes in our Scandinavian samples. For comparison purposes, we show the pooled results for the three haplotypes (B, D, and E) that carry the K allele of E23K. The frequencies of each haplotype in these samples are strikingly similar to those in the CEPH samples (compare these data with Fig. 3).