TABLE 4

Genotype-phenotype correlation of measures of insulin secretion and E23K

Nondiabetic discordant siblingsGeneral
Recessive
AlleleE (39)K (39)P*EE or EK (22)KK (22)P*
Ins index9.74 ± 5.86.89 ± 3.90.0069.64 ± 6.17.45 ± 4.4NS
Disp index7.76 ± 3.06.30 ± 3.50.067.69 ± 3.17.00 ± 4.0NS
Scandinavian control subjects GenotypeEE (168)EK (353)KK (153)PEE/EKKKP
Ins index5.31 ± 4.05.59 ± 4.94.52 ± 3.3EE vs EK:NS5.50 ± 4.74.52 ± 3.30.008
EE vs KK: 0.028
EK vs KK: 0.008
Disp index6.32 ± 3.85.91 ± 3.65.59 ± 3.7EE vs EK: NS6.04 ± 3.65.47 ± 3.8NS
EE vs KK: 0.08
EK vs KK: NS
  • Data are means ± SD. We calculated the insulinogenic index (Ins index) and insulin disposition index (Disp index) as described, and compared them across genotypes in nondiabetic siblings discordant for E23K and in all Scandinavian nondiabetic subjects for whom we had OGTT data (see text for details). Number of pairs or individuals is indicated in parentheses. NS, not significant.

  • *

    * Paired t test;

  • two-tailed;

  • one-tailed.