Transcription factors and other key genes involved in the development and maintenance of the endocrine pancreas
| Gene | Chromosome | Closest marker | Estimated distance between marker and gene | Multipoint LOD at D5S407 | ||
|---|---|---|---|---|---|---|
| Positive | Negative | |||||
| PBX1 | 1q23 | D1S196 | 3 cM | 1.13 | 1.25 | |
| NeuroD/β2 | 2q32 | D2S152 | 2.5 cM | 0.00 | 2.38 | |
| NKX6.1 | 4q21.2-22 | D4S1538 | 0.8 cM | 2.07 | 0.24 | |
| ISL1 | 5p11-q13 | D5S407 | 5 cM | ND | ND | |
| PAX4 | 7q32 | D7S530 | 1.7 cM | 5.26 | 0.20 | |
| NGN3 | 10q21.3 | D10S537 | 2.0 cM | 0.42 | 1.51 | |
| INS | 11p15.5 | TH | 8,000 bp | 2.00 | 0.58 | |
| PAX6 | 11p13 | D11S904 | 4 cM | 0.89 | 0.61 | |
| D11S907 | 1 cM | 0.38 | 2.04 | |||
| HNF1A | 12q24.2 | D12S366 | 1 cM | 0.40 | 1.11 | |
| D12S342 | 4 cM | 0.00 | 2.02 | |||
| IPF1/PDX1 | 13q12.1 | D13S192 | 0.2 cM | 0.00 | 2.74 | |
| HNF6A | 15q21.1-q21.2 | CYP19 | 1 cM | 2.06 | 0.53 | |
| ISL2 | 15q23 | D15S114 | 0.1 cM | 0.75 | 1.02 | |
| D15S125 | 1 cM | 0.99* | 1.25 | |||
| HNF3B | 20p11 | D20S112 | 5 cM | 0.32 | 1.75 | |
| IA-1 | 20p11 | D20S112 | 3 cM | 0.32 | 1.75 | |
| D20S107 | 4 cM | 0.00 | 3.13 | |||
| HNF4A | 20q12-q13.1 | D20S178 | 3 cM | 0.46 | 1.36 | |
Genotypes used for this interaction analysis were produced during a genome-wide scan for type 1 diabetes susceptibility genes (5). The interaction analysis was not presented in this report.
* LOD for positive multipoint interaction between D15S125 and chromosome 5 was 3.2 at D5S647. ND, not determined.