TABLE 2

Haplotypes in intron 1 of the ISL1 gene

HaplotypeISL1:5ISL1:6ISL1:7Observed (non-type 1 diabetes/ type 1 diabetes)Sequence, starting at intron position + 695, counting first base after first exon as +1
1WTAA565/561GCAATGCTCTAAAAAAAAAAAAAAAGAAAGAAAGAAAGAAAGAAAAAAACCTCCCAGAGTA*
2WTGA36/25---------------------G---------------------------------------*
3WT-4 bpAA10/8---------------------------------------------------------*
4WT+8 bpGG1/2------------------------GAAAGAAA--------------------G---------------*
  • *

    * This position is 86 bp from the 5′ end of exon 2. No significant difference in frequency of the different haplotypes between patients and control subjects was observed.