TABLE 3

Effect of leptin treatment in ob/ob mice

PBSLeptinPair fed
Body weight (g)54.8 ± 1.149.3 ± 0.5*50.1 ± 0.65*
Body fat (%)46.7 ± 1.337.1 ± 0.9*39.2 ± 0.5*
Food intake/day6.7 ± 0.83.14 ± 0.52*3.16 ± 0.4*
Temperature (oC)35.1 ± 0.136.9 ± 0.07*34.8 ± 0.17
Glucose (mg/dl)247 ± 10.3162 ± 5.2*195 ± 9.8
Insulin (ng/ml)20.5 ± 2.48.76 ± 1.3*14.7 ± 1.1
Triglyceride (mg/dl)136 ± 4.594 ± 1.3*127 ± 4.6
Corticosterone (ng/ml)254 ± 15188 ± 11.3203 ± 5.5
  • Data are means ± SE, n = 6–8. Lepob/ob mice were treated with leptin or PBS for 14 days. Pair-fed mice were restricted to the daily intake of leptin-treated mice.

  • *

    * P < 0.05 vs. PBS;

  • P < 0.05 vs. leptin.