TABLE 1

Effects of CNTF on body weight, plasma glucose, NCV, axonal structure of myelinated fibers and sensory nerve regeneration distance in control and diabetic rats

nControlControl + CNTFDiabeticDiabetic + CNTFP
Body weight (g)14–21244 ± 5a238 ± 4a165 ± 4b166 ± 7b<0.0001 (a vs. b)
Plasma glucose (mmol/l)14–213.2 ± 0.3a3.6 ± 0.7a28.2 ± 1.1b26.2 ± 1.0b<0.0001 (a vs. b)
MNCV (m/s)858.2 ± 0.8a58.1 ± 0.9a45.2 ± 0.9b52.2 ± 1.3c<0.001 (a, c vs. b)
SNCV (m/s)857.3 ± 1.8a58.4 ± 1.0a43.1 ± 1.3b49.3 ± 1.9c< 0.01 (a vs. b, c); < 0.05 (b vs. c)
Mean axonal diameter (μm)6–85.80 ± 0.16a5.94 ± 0.18a5.11 ± 0.19b5.41 ± 0.17c< 0.05 (a vs. b); NS (a, b vs. c)
Fibers ≤4 μm (%)6–811.9 ± 1.9a11.6 ± 2.3a27.4 ± 3.8b21.9 ± 3.2b< 0.05 (a vs. b)
Fibers ≥8 μm (%)6–825.0 ± 3.725.5 ± 3.715.0 ± 3.519.3 ± 2.7NS
Regeneration distance (mm)5–820.7 ± 0.6a21.0 ± 0.6a18.7 ± 0.8b21.9 ± 0.7a< 0.05 (a vs. b)
  • Data are means ± SE and were analyzed by one-way ANOVA, after which multiple comparisons were made with the Student-Newman-Keuls test. Axonal size-frequency distributions were derived from 4,032 (control), 3,040 (control + CNTF), 3,094 (diabetic), and 5,082 (diabetic + CNTF) myelinated fibers. NS, not significant.