TABLE 1

General characteristics of the animals

ControlDEX
Plasma glucose (mmol/l)8.7 ± 0.28.7 ± 0.1
Plasma insulin (ng/ml)3.2 ± 0.53.3 ± 0.7
Heart weight (g)1.4 ± 0.11.2 ± 0.001
Heart rate (bpm)313 ± 10312 ± 8
Rate pressure product (bpm × mmHg/1,000)32 ± 134 ± 1
Mean arterial pressure (mmHg)122 ± 6/93 ± 4125 ± 6/93 ± 6
  • Data are means ± SE for six animals in each group. DEX (1 mg/kg) was administered by intraperitoneal injection into control rats and the animals killed 4 h later. Hearts were perfused in the working mode for 1 h at a preload of 11.5 mmHg and an afterload of 80 mmHg. Mean arterial pressure was measured by an in vivo cannula inserted into the carotid artery.