TABLE 1

Clinical and biochemical characteristics of offspring of type 2 diabetic patients according to the UCP2 genotypes

−866G/G−866A/G−866A/AP55A/A55A/V55V/VP3′UTR D/D3′UTR D/I3′UTR I/IP
n (M/F)50/2561/2316/60.6846/2162/2619/70.9158/2756/2413/30.57
Age (years)36.9 ± 10.236.7 ± 10.741.0 ± 10.10.1136.1 ± 9.936.8 ± 10.542.8 ± 10.50.0236.4 ± 10.137.7 ± 10.740.8 ± 11.10.28
BMI (kg/m2)27.3 ± 5.927.7 ± 5.729.6 ± 6.40.2126.8 ± 6.128.3 ± 6.128.6 ± 5.00.2427.2 ± 5.828.2 ± 6.228.8 ± 5.10.46
Waist-to-hip ratio0.85 ± 0.110.86 ± 0.100.88 ± 0.110.380.85 ± 0.120.86 ± 0.100.89 ± 0.100.270.85 ± 0.100.86 ± 0.120.87 ± 0.100.74
Fasting glucose (mg/dl)88 ± 1190 ± 1290 ± 130.5689 ± 1289 ± 1191 ± 130.7990 ± 1190 ± 1288 ± 140.89
Fasting insulin (μU/ml)8.9 ± 4.89.5 ± 4.811.1 ± 6.20.208.4 ± 4.69.9 ± 5.110.3 ± 5.00.129.1 ± 4.89.9 ± 5.38.7 ± 4.10.44
Cholesterol (mg/dl)198 ± 34187 ± 39202 ± 380.10194 ± 30194 ± 42194 ± 360.9996 ± 32195 ± 43184 ± 300.52
HDL (mg/dl)56 ± 1553 ± 1253 ± 120.2655 ± 1554 ± 1253 ± 120.6954 ± 1454 ± 1353 ± 120.86
Triglycerides (mg/dl)103 ± 50102 ± 50107 ± 530.9396 ± 44108 ± 5196 ± 550.37101 ± 47110 ± 5392 ± 440.29
Glucose disposal (mg · kg−1 · min−1)8.7 ± 3.0*8.3 ± 2.56.6 ± 3.00.018.8 ± 3.08.1 ± 2.67.4 ± 2.90.098.8 ± 2.97.9 ± 2.77.3 ± 2.80.07
Insulin sensitivity index (μg · kg−1 · min−1/[μU/ml])1.42 ± 0.941.27 ± 0.85§0.76 ± 0.400.011.35 ± 0.981.29 ± 0.860.95 ± 0.510.321.33 ± 0.901.29 ± 0.890.82 ± 0.390.25
  • Data are means ± SD. Group differences of continuous variables were compared using ANOVA. Categorical variables were compared by χ2 test.

  • *

    * P < 0.0 vs. −866A/A, and

  • P < 0.046 vs. −866A/A genotype after Bonferroni correction;

  • P < 0.01 vs. −866A/A, and

  • §

    § P < 0.05 vs. −866A/A genotype after Bonferroni correction.