TABLE 2

Clinical and biochemical characteristics of offspring of type 2 diabetic patients according to the UCP2 haplotypes

GAD/GADGAD/AADGAD/GAIGAD/GVDGAD/AVDGAD/GVIGAD/AVIGVD/AVIAVI/GVIAVI/AADAVI/AVDAVI/AVIP
n (M/F)18/383/40/41/34/126/615/390/31/20/24/32/110.52
Age (years)35 ± 938 ± 1138 ± 1443 ± 1535 ± 1039 ± 1136 ± 1041 ± 546 ± 1736 ± 448 ± 939 ± 90.18
BMI (kg/m2)26.9 ± 6.224.5 ± 4.229.1 ± 731.4 ± 1.528.2 ± 5.325.9 ± 4.828.3 ± 6.225.6 ± 4.427.3 ± 3.234.2 ± 12.529.5 ± 5.229.1 ± 5.50.48
Waist-to-hip ratio0.84 ± 0.110.87 ± 0.070.88 ± 0.320.90 ± 0.020.86 ± 0.030.83 ± 0.070.86 ± 0.120.85 ± 0.080.96 ± 0.120.86 ± 0.100.94 ± 0.130.85 ± 0.080.66
Fasting glucose (mg/dl)89 ± 1190 ± 1584 ± 988 ± 591 ± 1285 ± 690 ± 1287 ± 4100 ± 1881 ± 1499 ± 1086 ± 120.34
Fasting insulin (μU/ml)8.7 ± 4.96.3 ± 0.56.9 ± 2.012.5 ± 3.810.2 ± 5.08.7 ± 4.69.6 ± 4.613.9 ± 8.05.3 ± 1.718.9 ± 17.012.1 ± 4.59.3 ± 4.10.06
Cholesterol (mg/dl)195 ± 30180 ± 33199 ± 30203 ± 16197 ± 36205 ± 53188 ± 42187 ± 35167 ± 9237 ± 38226 ± 38188 ± 330.33
HDL (mg/dl)55 ± 1654 ± 1561 ± 1150 ± 952 ± 1162 ± 1552 ± 1257 ± 1756 ± 861 ± 254 ± 1252 ± 130.78
Triglycerides (mg/dl)98 ± 45105 ± 4366 ± 21114 ± 45102 ± 56132 ± 65103 ± 45123 ± 47111 ± 60116 ± 94147 ± 5087 ± 400.28
Glucose disposal (mg · kg−1 · min−1)8.7 ± 3.09.6 ± 2.79.2 ± 4.68.1 ± 2.28.7 ± 3.08.8 ± 3.08.0 ± 2.49.7 ± 3.68.2 ± 2.63.7 ± 2.36.6 ± 2.97.2 ± 2.90.15
ISI (μg · kg−1 · min−1/ [μU/m])1.46 ± 1.030.75 ± 0.060.84 ± 0.670.77 ± 0.051.12 ± 0.611.61 ± 0.801.33 ± 0.961.86 ± 0.500.80 ± 0.090.10 ± 0.080.78 ± 0.280.82 ± 0.390.37
  • Data are means ± SD. Group differences of continuous variables were compared using ANOVA. Categorical variables were compared by χ2 test. Genotype combinations are in order as follows: −866G/A, 55A/V, and 3′UTR I/D. ISI, insulin sensitivity index.