TABLE 1

Body weight, kidney weight, and glomerular volume in WT and PKC-α−/− mice

Study groupnBody weight day 0 (g)Body weight week 8 (g)Kidney weight week 8 (mg)Kidney–to–body weight ratio (%)Glomerular VT (μm3 × 103)1 week 8*
WT control821.8 ± 1.125.9 ± 1.5229 ± 18.98.8 ± 0.4226 ± 27
WT diabetic1620.7 ± 1.022.7 ± 1.6257 ± 38.411.3 ± 1.4452 ± 79
PKC-α−/− control819.5 ± 2.024.3 ± 2.5191 ± 24.07.8 ± 0.4205 ± 27
PKC-α−/− diabetic1420.4 ± 1.321.9 ± 1.6§236 ± 33.4§10.8 ± 1.5387 ± 115
  • Data are means ± SD.

  • *

    * Glomerular tuft volume of superficial to midcortical glomeruli (n = 5 animals per group);

  • P < 0.01 versus control;

  • P < 0.05 versus WT control;

  • §

    § P < 0.05 versus PCK-α−/− control.