TABLE 2

Characteristics of wild-type and ob/ob working hearts perfused at 0.4 and 1.2 mmol/l palmitate

0.4 mmol/l palmitate wild type (insulin 0 nmol/l)0.4 mmol/l palmitate ob/ob (insulin 0 nmol/l)0.4 mmol/l palmitate wild type (insulin 1 nmol/l)0.4 mmol/l palmitate ob/ob (insulin 1 nmol/l)1.2 mmol/l palmitate wild type (insulin 0 nmol/l)1.2 mmol/l palmitate ob/ob (insulin 0 nmol/l)1.2 mmol/l palmitate wild type (insulin 1 nmol/l)1.2 mmol/l palmitate ob/ob (insulin 1 nmol/l)
Body weight (g)25.16 ± 0.71 (8)50 ± 2.88 (8)*24.21 ± 0.79 (8)48.73 ± 1.59 (9)*23.65 ± 0.95 (6)42.94 ± 1.31 (6)*26.34 ± 0.85 (8)53.17 ± 1.04 (6)*
WHW (mg)149.63 ± 5.29 (8)195.75 ± 5.55 (8)*131 ± 2.52 (8)200.22 ± 3.65 (9)*202.57 ± 6.26 (6)206.08 ± 5.21 (6)257.04 ± 11.68 (8)224.70 ± 9.81 (6)*
Dry heart weight (mg)29 ± 0.54 (8)34.63 ± 1.90 (8)*28.38 ± 1.09 (8)35.89 ± 1.43 (9)*26.62 ± 2.48 (6)30.08 ± 1.12 (6)35.04 ± 1.76 (8)31.85 ± 1.99 (6)
Heart rate (beats/min)287.03 ± 9.19 (8)293.75 ± 12.25 (8)322.19 ± 7.17 (8)307.2 ± 7.51 (9)336.57 ± 13.03 (6)276.02 ± 20.91 (6)*268.45 ± 13.22 (8)278.55 ± 10.10 (6)
LVSP (mmHg)87.85 ± 1.54 (8)82.88 ± 1.67 (8)89.75 ± 2.46 (8)80 ± 1.73 (9)*85.83 ± 3.81 (6)85.42 ± 3.60 (6)89.69 ± 4.64 (8)92.08 ± 4.59 (6)
LVEDP (mmHg)48.23 ± 0.64 (8)46.13 ± 2.21 (8)34.13 ± 0.73 (8)33.92 ± 0.28 (9)60.88 ± 3.54 (6)59.46 ± 3.56 (6)67.59 ± 4.11 (8)65.21 ± 4.15 (6)
LV DevP (mmHg)39.63 ± 1.28 (8)36.75 ± 1.69 (8)55.63 ± 1.92 (8)46.08 ± 1.68 (9)*24.96 ± 0.85 (6)25.96 ± 1.22 (6)22.09 ± 0.83 (8)26.88 ± 0.95 (6)*
Coronary flow (ml/min)3.05 ± 0.04 (8)3.07 ± 0.04 (8)2.87 ± 0.06 (8)3.02 ± 0.04 (9)2.76 ± 0.14 (6)2.98 ± 0.12 (6)2.61 ± 0.07 (8)3.30 ± 0.12 (6)*
Aortic flow (ml/min)8.42 ± 0.40 (8)7.67 ± 0.41 (8)9.05 ± 0.50 (8)7.24 ± 0.34 (9)*6.53 ± 0.38 (6)6.17 ± 0.54 (6)4.37 ± 0.28 (8)8.08 ± 0.51 (6)*
Cardiac output (ml/min)11.47 ± 0.41 (8)10.73 ± 0.40 (8)11.91 ± 0.53 (8)10.25 ± 0.34 (9)*9.30 ± 0.43 (6)9.15 ± 0.61 (6)6.98 ± 0.30 (8)11.38 ± 0.49 (6)*
Cardiac power (mW/g)36.89 ± 2.14 (8)26.31 ± 1.62 (8)*53.49 ± 3.67 (8)31.92 ± 2.25 (9)*15.99 ± 1.90 (6)17.41 ± 1.34 (6)10.33 ± 0.73 (8)23.62 ± 1.62 (6)*
  • Data are means ± SE (no. of heart perfusions). LVSP, left ventricular systolic pressure; LVEDP, left ventricular end-diastolic pressure; LV DevP, left ventricular developed pressure.

  • *

    * P < 0.05 vs. wild type perfused under similar conditions.