TABLE 2

Incidence of DN per 1,000 person-years for the siblings of probands with type 1 diabetes according to nephropathy status in the proband and attained age

Attained age (years)Proband without DN
Proband with DN
DN+-to-DN rate ratio
Person-yearsCases (n)Incidence (95% CI)Person-yearsCases (n)Incidence (95% CI)
0–141,034.60590.212.5 (0.04–9.4)
15–191,053.4109.5 (4.6–17.5)599.2911.5 (6.8–28.5)1.6
20–241,164.9119.4 (4.7–16.9)613.31829.0 (17.4–46.4)3.1
25–291,220.91713.9 (8.1–22.3)558.21934.0 (20.5–53.2)2.4
30–341,106.01513.6 (7.6–22.4)469.61422.8 (16.3–50.0)2.2
35–39732.8912.3 (5.6–23.3)368.8510.4 (4.4–31.6)1.1
≥40665.646.0 (1.6–15.4)395.01127.0 (13.9–49.8)4.6
All6,978.2669.5 (7.3–12.0)3,594.37721.4 (16.9–26.8)2.3
  • DN+, presence of nephropathy and includes ESRD; DN, absence of nephropathy.