TABLE 2

Summary of anti-growth factor neutralization data

SampleSpecific activity*rcorrAnti-IGF
Anti-PDGF
Specific activityrcorr% InhibitionSpecific activityrcorr% Inhibition
136.50.9111.30.9569.032.00.9712.3
272.00.9721.40.8170.262.10.9413.7
325.30.969.90.9361.018.70.9726.2
439.60.9918.10.9954.236.30.998.3
567.20.9722.90.9465.956.30.9616.7
612.60.987.20.9843.310.90.9813.9
7137.40.9787.90.9640.496.70.8629.6
862.50.9437.50.9140.062.30.960.2
934.70.9318.10.8247.832.20.957.2
1077.30.9739.90.9648.461.10.9720.9
% Inhibition + anti-IGF% Inhibition + anti-PDGF
PDR (n = 10)54.04 ± 11.1614.86 ± 8.42
PDR without hemorrhage (n = 4)63.62 ± 6.5015.13 ± 6.66
PDR with hemorrhage (n = 6)47.66 ± 8.8014.68 ± 9.41
  • Data are means ± SD unless otherwise indicated.

  • *

    * Specific activity refers to calculated percent contraction per ODU protein.

  • rcorr, correlation coefficient.

  • % Inhibition is calculated as 100 − specific activity plus antibody/specific activity without antibody.