TABLE 1

The effects of TZDs on insulin secretion and glucose-stimulated insulin secretion

ModelPlasma
Insulin secretionGlucose-stimulated insulin secretionReference
GlucoseInsulin
HIT-T15 cellsIncreased insulin secretion in 11 mmol/l glucose38
Primary islets from humansNo changeNo change30
Primary islets from ZDF ratsDecreaseIncrease39
Type 2 diabetic humansDecreaseDecreaseDecreaseIncrease4
db/db miceDecreaseIncrease*Increased intracellular insulin content of β-cells35
db/db miceDecreaseNo changeIncreased intracellular insulin content of β-cells37
ob/ob miceDecreaseDecreaseIncrease34
KK miceDecreaseDecreaseIncrease34
ZDF ratsDecreaseDecreaseDecrease, increased insulin transcriptionIncrease5,33,34,36,40
  • *

    * NS.