TABLE 1

Effect of PPAR-γ activation

Preincubation (48 h)Insulin in medium (ng/ml)
Insulin content (μg/ml)
Ratio
3.37.51120P3.37.51120P3.37.51120P
[11 mmol/l]G19 ± 482 ± 5107 ± 11103 ± 102.0 ± 0.11.8 ± 0.21.9 ± 0.11.8 ± 0.11.0 ± 0.24.4 ± 0.35.3 ± 0.65.7 ± 0.7
[11 mmol/l]G + [0.2 μmol/l]γ20 ± 589 ± 2113 ± 8154 ± 14*1.9 ± 0.12.1 ± 0.12.0 ± 0.11.9 ± 0.1NS1.0 ± 0.34.0 ± 0.15.3 ± 0.57.6 ± 0.9NS
[11 mmol/l]G + [0.4 μmol/l]γ20 ± 575 ± 2124 ± 4156 ± 14*2.1 ± 0.12.1 ± 0.22.0 ± 0.12.0 ± 0.1NS0.9 ± 0.33.6 ± 0.26.0 ± 0.47.3 ± 0.7NS
  • * P < 0.01 vs. [11 mmol/l]G; n = 33 in each row. [11 mmol/l]G, 11 mmol/l glucose; [0.2 μmol/l]γ, 0.2 μmol Ro4389679-000-001 (PPAR-γ agonist); [0.4 μmol/1]γ, 0.4 μmol/l Ro4389679-000-001 (PPAR-γ agonist).